Tuesday, November 3, 2015

Journal of the American College of Cardiology

Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy

CardioCell’s Phase IIa chronic heart failure clinical trial is referenced in a peer-reviewed article now available in the Journal of the American College of Cardiology. The paper illustrates the importance the field ascribes to a stem cell strategy to treat either ischemic or non-ischemic cardiomyopathy. Entitled “Mechanisms Contributing to the Progression of Ischemic and Nonischemic Dilated Cardiomyopathy: Possible Modulating Effects of Paracrine Activities of Stem Cells,” the paper authors include CardioCell’s Scientific Advisory Board members Drs. Stephen E. Epstein, Arshed A. Quyyumi, Mihai Gheorghiade and Javed Butler.

The full article is available online via subscription or for purchase at the Journal of the American College of Cardiology, or contact CardioCell for more detail.


Over the past 1.5 decades, numerous stem cell trials have been performed in patients with cardiovascular disease. Although encouraging outcome signals have been reported, these have been small, leading to uncertainty as to whether they will translate into significantly improved outcomes. A reassessment of the rationale for the use of stem cells in cardiovascular disease is therefore timely. Such a rationale should include analyses of why previous trials have not produced significant benefit and address whether mechanisms contributing to disease progression might benefit from known activities of stem cells. The present paper provides such a reassessment, focusing on patients with left ventricular systolic dysfunction, either nonischemic or ischemic. We conclude that many mechanisms contributing to progressive left ventricular dysfunction are matched by stem cell activities that could attenuate the myocardial effect of such mechanisms. This suggests that stem cell strategies may improve patient outcomes and justifies further testing.

(J Am Coll Cardiol 2015;66:2038–47) © 2015 by the American College of Cardiology Foundation.